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Now Sam-e 200 mg Tablets, Nervous System Support, 30 ct Construction Tools Four dry erase markersSAMe (S adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain, contributes to the maintenance of healthy cell membrane function, and influences cartilage metabolism