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evaluated the willingness of 5,000 women to use MB as a diagnostic sample, with the results indicating that 87% of participants supported its utilization for testing (Wong et al., 2018)
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This hypothesis is supported by the proposed mechanism that implies the inhibition of PGHS-2-derived PGE 2 , by coxibs, which can then reduce the anti-apoptotic mitochondrial protein Bcl-2 (which offers protection against bile acid-induced apoptosis), leading to hepatocyte apoptosis [202]
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