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HCA was also shown to suppress T-bet expression, which is involved in the induction of IFN-γ, suppression of IL-2 in TH cells, and suppression of T-bet-stimulated Th1 cell differentiation

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On the contrary, alopecia areata and vitiligo mostly appear simultaneously, indicating that the two diseases could share the exact pathogenetic mechanism (Rios-Duarte et al., 2023)