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Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display

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Rando’s lab showed that heterochronic parabiosis restores the activation of the NOTCH signaling pathway and improves skeletal muscle regeneration and stem cell activation in the old mice [17] but also induces heightened WNT signaling and fibrosis that suppresses stem cell function and regenerative myogenesis in the young mice [25]