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Beyond systemic symptoms, vitamin B12 deficiency is also associated with a range of oral manifestations, including burning mouth syndrome, recurrent aphthous ulcers, mucosal inflammation, and trigeminal nerve-related pain, which are often underdiagnosed or misattributed to other conditions (Bao et al., 2021

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Additionally, cancer patients often manifest decreased levels of vitamin B6, and it seems that vitamin B6 deficient cancer cells appear to be much more resistant to stress-induced death, e.g., in lung cancer 33 , thus reducing the effects of chemotherapy

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