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MAPK/ERK Cascade and GILZ Homology Computational and molecular research identified structural homology between DSIP and GILZ (glucocorticoid-induced leucine zipper) — a glucocorticoid-regulated protein that prevents Raf-1 activation and thereby inhibits ERK phosphorylation via the MAPK cascade

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PEM is a debilitating aspect of all three conditions, leading patients to pace their activities to avoid triggering these symptoms (Stussman et al., 2023