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Subcutaneous injection adverse events in published peptide research are predominantly mild and local: injection site erythema (redness) occurs in approximately 5–15% of subjects, pruritus (itching) in 3–10%, and subcutaneous nodule formation in less than 2%

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The coprecipitation method created a curcumin-β-cyclodextrin inclusion complex, significantly increasing curcumin’s water solubility from 0122 to 0.72100 mg/mL