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Additionally, we did not examine bone mass which is tightly linked to mitochondrial health in skeletal muscle (Tian et al., APOE4 and APOE3 mice regardless of sex suggests that genotype-dependent effects on muscle protein expression are likely not explained by differences in the relative amounts of each fiber type, which display unique proteomic expression profiles (Murgia et al., Defects in mitochondrial respiratory chain function in skeletal muscle of a mouse model of autosomal dominant AD are not evident until 12 months of age, despite early molecular changes detected in skeletal muscle (Monteiro-Cardoso et al., APOE4 female mice despite normal respiratory function may reflect an underlying respiratory chain defect that is compensated for by increased production of proteins involved in oxidative metabolism
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Oxidative stress as a regulator of gene expression in the vasculature
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