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In glaucoma, mitochondrial Zn²⁺ accumulation induces depolarization, increased permeability and fission, including mPTP opening and mitochondrial fragmentation occurring before retinal ganglion cell apoptosis 156
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A Cu(II) complex with the Dp44 mT ligand, which is presently in clinical trials (NCT02688101), exhibited the highest anticancer competency compared to the Cu(II) complex with 3AP through balancing between moderate depletion of GSH level and ROS generation
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