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The clinical potential of this approach is underscored by the approval of istradefylline in Japan and the United States as an adjunct therapy for PD patients experiencing motor fluctuations, representing the most advanced A 2A receptor antagonists in clinical development [480–482]

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There is currently no established treatment for MAFLD and MASH other than interventions that encourage lifestyle changes and the use of medicines to control or treat metabolic disorders (95, 96)