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These cells secrete pro-inflammatory cytokines such as interferon-gamma (IFN-γ), interleukin-1 beta (IL-1β), and interleukin-17 (IL-17), which stimulate the activation and proliferation of orbital fibroblasts and adipocytes ( in vitro model of TGF-β-induced orbital fibroblast activation, inhibition of TGF-β reduced levels of α-SMA, type I collagen, Timp-1, and vimentin, and decreased TGF-β-induced phosphorylation of ERK, p38, JNK, and NF-κB (55), while decreased histone deacetylase 2 expression in ocular tissues enhances T cell proliferation and inflammation in thyroid eye disease (56)

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Higher dietary inflammation is associated with increased odds of depression independent of Framingham Risk Score in the National Health and Nutrition Examination Survey