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The pseudo four-fold symmetrical arrangement of LBDs (Figure 4D) was first observed in the SYM2081-bound structure of GluK2 with the apparently closed ion channel pore and was proposed to represent a desensitized state (Meyerson et al., 2016)
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Glucose, as a key substrate for energy metabolism, exhibits a concentration gradient in the normal IVD, decreasing from about 5 mM in the outer annulus fibrosus (AF) to about 1 mM in the central nucleus pulposus (NP) (Shirazi-Adl et al., 2010)
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