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With approximately 80%–90% of its fibers being afferent (from the gut to the brain), it transmits information about the state of the intestinal lumen, including the presence of microbial metabolites and cytokines, directly to brainstem nuclei, such as the nucleus of the solitary tract (NTS) ( SCFAs, primarily butyrate, propionate, and acetate, are the main products of fiber fermentation by the microbiota (Wadan et al., 2025)
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