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According to 9 , this first hypothesis has been subsequently revised in a “multiple parallel-hit” model in which, in the presence of a significant accumulation of fat in hepatocytes and systemic and hepatic insulin resistance, multiple simultaneous alterations lead to an imbalance between the antilipotoxic protection system of the liver (mitochondrial ß-oxidation) and the free radical production in gut and adipose tissue, resulting in endoplasmic stress, oxidative stress, and hepatocyte apoptosis
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