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During the initial stages of pregnancy, an organ called the placenta develops within the uterus

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As μ-opioid receptors induce neuronal hyperpolarization through the activation of GIRK channels in the vlPAG (Ingram et al., 2008), RGS proteins positively regulate the coupling between μ-opioid receptors and GIRK channels in the vlPAG (McPherson et al., 2018)