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Hyperpigmentation, the darkening of the skin due to excess melanin production, is one of the most common skin concerns affecting millions of people worldwide

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The most physiologically relevant reversible redox post-translational modifications (PTMs) are disulfide bonds, sulfenic acids, S-glutathione adducts, S-nitrosothiols and to a lesser extent S-sulfenyl-amides, thiosulfinates and S-persulfides