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Because BCAT is not present in hepatocytes, dietary BCAA, as well as gut microbiota-derived BCAA, pass through the liver and are deaminated by BCAT in other tissues, predominantly within skeletal muscle

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Inhibiting sphingosine kinase 2 derived-sphingosine-1-phosphate ameliorates psoriasis-like skin disease via blocking Th17 differentiation of naïve CD4 T lymphocytes in mice