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As a result, PI3K catalyzes the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP 2 ), forming phosphatidylinositol 3,4,5-trisphosphate (PIP 3 ) (86), a docking site that recognizes proteins with a specific domain, the pleckstrin homology (PH) domain, including the phosphoinositide-dependent protein kinase (PDK) and protein kinase B (Akt) kinases (Ser/Thr kinases)
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