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Using a biochemical assay to detect and quantify protein-bound persulfide, the production of the sulfide ions in thiol-based reactions was shown to result from the cleavage of the persulfide carried by NFS1 (Figure 2B, red chart), whereas it is the persulfide of ISCU that is cleaved in FDX2-based reactions (Figure 2B, blue chart) (Parent et al., 2015
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