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Additionally, biosynthesis of amino acids, purine metabolism, glycolysis/gluconeogenesis, tyrosine metabolism, and other amino acid and carbohydrate metabolism-related pathways were significantly enriched, with overall energy metabolism-related pathways showing higher enrichment degrees and gene numbers than in summer-form ( Figure 2 )

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Based on the findings of this study, it is hypothesized that LOX activity may enhance the accumulation of lipid hydroperoxides within cells, thereby promoting ferroptosis