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The BBB is an intricately designed barrier that plays essential roles in CNS protection, brain homeostasis, and neuronal health [19,138,185]

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GlyNAC supplementation differentiates itself as a physiologic approach to correct glutathione deficiency, because it harnesses the cellular regulation of glutathione synthesis and reduces the risk of reductive stress, a phenomenon where excessive antioxidant intake pushes oxidation too low and disrupts normal cellular signaling