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Thus, there were increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy in glaucomatous rats [11]

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Vitamin B12 is involved in carbohydrate, fat and other metabolism, involved in the biosynthesis of essential amino acids and proteins in animals: can promote the development and maturation of red blood cells, has an always important role