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Moreover, we found that for both CD4 and CD8 CAR T cells, HK and G6PD expression levels showed a significant correlation, further supporting the potentially coupled activity of the two step-limiting rate enzymes of glycolysis and the PPP, respectively (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Pieber TR, Roitelman J, Lee Y, Luskey KL, Stein DT