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Notably, AII (rod) amacrine cells release glycine at their synapses with OFF BPCs, other amacrine cells, and RGCs, parsing out signals from the rod photoreceptors to both the ON and OFF pathways in the INL—with transmission of signals from AII to the ON pathway relying on gap junctions instead of glycine

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2 Overview of osteoarthritis and ferroptosis 2.1 Pathogenic mechanisms of osteoarthritis OA is a common degenerative joint disease marked by gradual cartilage degradation, destruction of subchondral bone structure, synovial inflammation, and clinical symptoms such as joint pain