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Instead of reiterating the psychedelic mechanisms detailed in Section 6, it is essential to emphasize that ongoing studies are exploring how functional selectivity, particularly through the β -arrestin pathway, could lead to non-hallucinogenic anxiolytics 33 , 90
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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: → In one clinical trial, AOD‑9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)