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United Kingdom Prospective Diabetes Study 24 (1998): A 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy

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Yet even if an individual appears to fit the profile, we have no way of knowing with confidence whether that person is a “true” LMHR, nor do we have meaningful evidence that the long-term consequences of elevated LDL-C are any different in this population from any other population