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In a first study ( 2 O 2, GPX activity, glutathione disulfide (GSSG), cell proliferation, HA and pro-inflammatory cytokines were measured, in the presence or absence of selenium-(Methyl)-selenocysteine (SeMCys)
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Consequently, ID-ADCs may be misrouted to non-permissive compartments, resulting in insufficient payload release and impractically high dosing requirements ( 10.3 Structural and biochemical knowledge gaps Rational ID-ADC design is constrained by limited structural and biochemical data