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NAD+ BENEFITS Selective NNMT inhibition — substrate-site targeting with minimal off-target activity in preclinical models NAD+ salvage modulation — studied for increasing intracellular NAD+ and SAM availability Adipose metabolism — investigated for suppression of adipocyte lipogenesis in 3T3-L1 models Small molecule — distinct mechanism from peptide-based metabolic compounds (GLP-1 agonists, etc.) Defined pharmacology — IC₅₀ of 1.2 μM confirmed in published enzymatic assays WHAT RESEARCHERS LOOK AT NNMT enzyme inhibition kinetics and SAM/1-MNA substrate balance NAD+ and SAM level changes in adipocyte and hepatocyte cell models Lipogenesis suppression in 3T3-L1 differentiated adipocyte assays Polyamine flux enzyme upregulation (ODC, SSAT) and histone methylation In vivo efficacy in diet-induced obesity (DIO) murine models QUICK SPECS Form: Lyophilized powder Net per vial: 10 mg Purity: ≥99% (HPLC verified) Identity: MS-verified (per COA) Storage: -20°C recommended, protect from light and moisture Note: Supplied as iodide salt form