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Higher-risk groups include: People with gluten sensitivity People with celiac disease People with autoimmune disease People with chronic fatigue People with chronic lung mucus or recurrent respiratory burden People using acetaminophen People with alcohol exposure People with mold or chemical exposure People with chronic digestive symptoms People after bariatric or intestinal surgery Older adults Athletes under heavy training load People with poor protein intake Vegans or vegetarians not carefully balancing amino acids People with PCOS or fertility concerns People with chronic inflammatory disease In my clinical practice, people with gluten sensitivity, mold exposure, or pre-existing autoimmune conditions often benefit from NAC supplementation