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Copper Delivery and Enzyme Cofactor Activity GHK acts as a physiological copper chaperone, binding copper(II) with high affinity (K d approximately 10 −14 M) and facilitating its delivery to copper-dependent enzymes

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Understanding this distinction helps explain why many commonly used pain medications— particularly corticosteroids —can provide short-term symptom relief while quietly worsening long-term metabolic, immune, and tissue health