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It occurs in protein-rich foods such as meat, fish and nuts

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This is due to a favorable electrostatic attraction that induces tight junction opening, resulting in enhanced paracellular transport of ions, macromolecules, and hydrophilic drugs across cell barriers, and importantly, improves the BBB penetration of drug-loaded nanoparticles via adsorptive-mediated endocytosis (Roney et al., 2005