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Although immune dysfunction is clear in ME/CFS, further studies using defined cohorts, standardised assays, and new technologies are required to determine specific patterns (488), contradicting the hypothesis that ME/CFS could be caused by a clearance failure of the pathogenic microbe ( Table 2 Immune alterations present in ME/CFS and changes evident in B cells, T cells, and NK cells (253–255, 278, 445–482)