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What it is / mechanism 5-Amino-1MQ is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that methylates nicotinamide — consuming the methyl donor SAM in the process — to form 1-methylnicotinamide, diverting nicotinamide away from the NAD+ salvage pathway
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Newly synthesized saturated fatty acids can be cytotoxic under hypoxic conditions, particularly when desaturation (via SCD1) and FAO are suppressed
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