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In particular, the BBB regulates the trafficking of ions (Na+, K+, Ca2+), water, nutrients, metabolites, neurotransmitters (glutamic acid, tryptophan), plasma proteins (albumin, fibrinogen, immunoglobulins), cells from the immune system and also xenobiotics (drugs) in and out of the brain

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In the donor brain death (BD) rat model, the fusion protein attenuated the inflammatory response induced by brain death and significantly enhanced the insulin secretion function of transplanted islets in response to glucose stimulation both in vitro and in vivo (140)