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Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition

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•Advanced human model systems, especially SC-islets, are essential for establishing causal mechanisms, enabling researchers to link genetic risk, viral stressors, and immune responses in a human-relevant context and guide the development of targeted preventive therapies