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Therefore, it would be more informative to explore the role of acupuncture on gastrointestinal peptides via vagal nerve in gastrointestinal dysmotility (Figure 3)
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The reason retatrutide and the approved GLP-1s are titrated up over months is side effects: in the Phase 2 trial, jumping to high doses without titration nearly doubled gastrointestinal side effects for the same weight loss (The Lancet, 2023)
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