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Studies also show that compared to those who only have localized pain or itchiness around the injection site, people reporting symptoms all over the body (fever, chills, muscle pain, nausea, vomiting, headache, and/or moderate to severe fatigue) generate greater antibody response

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The Increlex label explicitly contraindicates use in patients with active or suspected neoplasia and notes that active or suspected malignancy should prompt discontinuation