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Numerous studies have found that it exerts its effects by modulating the activity of neurotransmitters, such as dopamine and serotonin, thereby promoting restful sleep and enhancing recovery

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This so-called autocrine loop of ROS by HSCs is regarded as mechanism corresponding to the autocrine loop of TGF-β which HSCs produce in response to this cytokine with an increased collagen expression in the injured liver (Itagaki et al., 2005)