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1990s high risk, 0.3), which was comparable to the U.S

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Unlike nociceptive or neuropathic pain, pharmacotherapy often yields modest effects and significant adverse effects [46, 396, 397, 398], necessitating a primary focus on nonpharmacological, mechanism‐based interventions that target central dysregulation, dysfunctional pain processing, and associated psychosocial comorbidities [46, 264, 398, 399]

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