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Although elemental selenium, selenium dioxide, and selenium sulfide exhibit limited bioavailability, compounds such as selenite, selenate, and selenium-enriched amino acid analogs are more amenable to absorption, particularly when synergized by vitamins A, D and E ( Figure 1 Selenium is metabolized through the liver, and synthesized and exported to selenoprotein P (SelP), which is eventually secreted into the bloodstream, serving as a vital conduit for the distribution of selenium to peripheral tissues or organs ( The biological effects of Se are exerted primarily through the form of selenoproteins synthesized by the selenometabolic system
