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Updated phase 3 titration pathway The phase 3 schedule uses the following escalation: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Weeks 9-12: 8mg weekly Week 13+: Maintenance dose (4mg, 9mg, or 12mg depending on assignment) The introduction of a 9mg dose option is interesting
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Plus, thiamin does not have a tolerable upper intake level (UL)—therefore, supplementing with thiamin is not likely to cause adverse effects if taken in excess
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