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In this context, they may act in a cell-intrinsic manner or by modulating the microenvironment of the stem cell niche, when existing, by: (i) producing matricellular components, namely growth factors or mitogens, (ii) activating signaling pathways (e.g., Wnt, Hedgehog, retinoic acid), (iii) proliferating in early and restricted time-period of injury, or (v) creating the scaffold that guides regeneration and immunomodulation