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Kratom has been valued for multiple purported medicinal properties since at least the 19th century (Field, 1921)

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However, the literature indicates that cortistatin exerts various effects on the nervous system and peripheral tissues that are not shared with somatostatin [12], probably due to the capacity of cortistatin, but not somatostatin, to bind to receptors other than sstr, including ghrelin receptor (GHSR1), Mas gene-related receptor X-2, and a still-unidentified cortistatin-selective receptor [13,14]