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Whether triggered by DHT sensitivity, sebaceous gland hyperactivity, oxidative stress, environmental aggressors, or autoimmune dysregulation, inflammation around the hair follicle creates a hostile microenvironment in which normal follicular cycling cannot be sustained
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Atomic coordinates have been deposited in the Protein Data Bank (PDB) under accession codes 8DH8 (LepR D1– D7 receptor complex), 8DH9 (LepR D3–D7 receptor complex), and 8DHA (LepR focused interaction)
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