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What this does NOT prove: that it preserves lean mass without resistance training, that it is safe long-term without Phase 3 data, or that results in the trial population (adults with obesity, BMI 30 or above) translate to lean young men
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Pegylated arginine deiminase (ADI-PEG-20), which duplicates arginine and increases tumor stress and cytotoxicity, increased the number of tumor-infiltrating T cells in phase I studies and was safe in combination with anti-PD-1 antibody, but with an increased risk of neutropenia
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