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Indeed, these behavioral improvements are clear indicators of gut microbiota modulation in which Akkermansia may increase along with beneficial SCFAs such as acetate and propionate, and the decrease of isobutyrate and stable n-butyrate levels in the gut

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Platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), tumor necrosis factor-beta (TNF-β), and thrombin also activate NOX in vascular smooth muscle cells (VSMC)