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Long-term intervention studies further confirm that resistance training increases expression of electron transport chain proteins and dynamics-related regulatory molecules in aged skeletal muscle ( Similarly, a report demonstrated that 10 weeks of resistance training significantly upregulated mRNA expression of the Apelin signaling pathway, vitamin D receptor, and spermine oxidase in skeletal muscle of middle-aged individuals, with these increases positively correlated with enhanced maximal oxidative phosphorylation capacity ( via the endoplasmic reticulum unfolded protein response