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[10] As a general clinical principle: Retest HbA1c no sooner than three months after commencing B12 replacement therapy, and ideally once haematological recovery has been confirmed Confirm haematological recovery — normalisation of MCV and haemoglobin — before interpreting the repeat HbA1c as reliable Use interim glucose monitoring — such as fasting plasma glucose, OGTT, or self-monitored blood glucose (SMBG) — to assess glycaemic control during the treatment period

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This explains how the effect of one mechanism affects the results of TB-500 in research papers – migration of endothelial cells, tube formation, stabilization of vessels, and anti-inflammatory signaling