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Dosing Calculation Examples If you reconstituted a 5 mg vial with 2 mL bacteriostatic water , your concentration is 2,500 mcg/mL: For 250 mcg dose: Draw 0.10 mL (10 units on insulin syringe) For 300 mcg dose: Draw 0.12 mL (12 units on insulin syringe) For 500 mcg dose: Draw 0.20 mL (20 units on insulin syringe) AOD-9604 Administration Guide Proper subcutaneous injection technique ensures optimal absorption, minimizes discomfort, and reduces risk of injection site reactions

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The reduced folate transporter also mediates uptake of methotrexate by cells