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Voici quelques-unes des bactéries les plus utilisées pour produire la B12 : Aérobies : Pseudomonas denitrificans, Rhodobacter capsulatus, Rhodobacter sphaeroides, Sinorhizobium meliloti Anaérobies : Bacillus megaterium, Propionibacterium shermanii, Salmonella typhimurium La première souche bactérienne utilisée pour sa synthèse fut Lactobacillus lactis Doner , bien qu’on sache aujourd’hui que d’autres bactéries comme Pseudomonas denitrificans et Propionibacterium shermanii soient également utilisées en laboratoire pour la production de suppléments